SD and translation

Sleep deprivation (SD) impairs protein synthesis in the brain by specifically affecting the AMPK-mTORC1-4EBP2 axis.  This project examines how sleep deprivation affects raptor signaling in the brain, which is part of the mTORC1 signaling pathway.

4EBP2 and memory

We have made several viral vectors that express mutant 4EBP2 in mouse brain.  This project examines how expression of mutant 4EBP2 affects cognition and behavior with sleep deprivation.

RNA granules

Given that there is dysregulated translation with sleep loss, we are examining whether RNA granule formation and clearance is altered with sleep loss.

FXS and behavior

Fragile X Syndrome (FXS) patients have several behavioral impairments. We are currently analyzing a mouse model of FXS to determine if it recapitulates many of these behavioral phenotypes.

Spina bifida and weight management

Spina bifida patients are concerned about the best practices for weight management in the midst of their condition. We are currently surveying best practices for weight management as part of a joint project with the Spina Bifida Association.

Mentorship

Mentorship has a variety of styles and forms. We are currently conducting a study examining the most effective practices of mentorship.